Does Arimidex Really Work?
ARIMIDEX side effects:
Treatment with ARIMIDEX (pronounced a-RIM-ih-dex) may cause side
effects. In the early breast cancer clinical trial, the most
common side effects seen with ARIMIDEX include hot flashes, joint
symptoms, weakness, mood changes, pain, sore throat, nausea and
vomiting, depression, high blood pressure, osteoporosis, swelling
of arms/legs, and headache. Fractures (including fractures of
the spine, hip, and wrist) occurred more frequently with ARIMIDEX
than with tamoxifen (10% vs 7%).
If you want to learn about the possible side effects of ARIMIDEX,
it may help to understand the findings of the early breast cancer
clinical trial, called the ATAC study ("ARIMIDEX, Tamoxifen
Alone or in Combination"). In this study, side effects and
complications of treatment with ARIMIDEX were compared with those
of the anti estrogen medication tamoxifen.
ESTROGEN = TUMOR GROWTH
To understand how ARIMIDEX works, you first need to understand
the meaning of several key terms:
Aromatase is an enzyme that is found in the liver, fat, muscle,
and breast cancer cells. In women who are postmenopausal, aromatase
changes androgens (hormones produced in the adrenal glands) to
the hormone estrogen. Some breast cancer tumors grow when the
hormone estrogen is present.
ARIMIDEX is a medication called an aromatase inhibitor. ARIMIDEX
works by blocking aromatase, therefore reducing the amount of
estrogen in the body AROMATASE.
Aromatase is an enzyme required for the conversion of androgens
to estrogens. Aromatase inhibitors thus decrease the concentrations
of estrogens in the body and are effective against tumors that
depend on estrogen for growth.
They are usually used as second-line therapy (after tamoxifen)
for the treatment of breast cancer in postmenopausal women.
AROMATASE, an enzyme found in the liver, is responsible for
the conversion of the androgens ANDROSTENEDIONE and TESTOSTERONE
into the estrogens ESTRONE and ESTRADIOL. By inhibiting aromatase
the body produces less estrogen and maintains a higher testosterone
state.However, only this single pathway is blocked. There are
many other pathways that produce Estrogen , and are independent
of Aromatase that are not blocked by Arimidex.
The metaphor is ...like having the Police block traffic only
on one street into the City, when there are another 5 streets
leading into the City.
Other sources of Estrogen, independent of Aromatase are:
- The Adrenals - produces Estrogens that are not blocked by
Arimidex.
- The Adipose Tissue (Fat) - produces Estrogens that are not
blocked by Arimidex.
- The Ovaries - produces 700% more Estrogens than inhibited
by Aromatase , also not blocked.
- The Environment. - xeno-estrogens , which can be the most
toxic are not blocked by Arimidex.
Logic would be to try and block Estrogen from ALL sources
, not just one pathway as does Arimidex. Therefore, Tamoxifen
, if tolerated, could be a better choice. Unfortunately , Tamoxifen
only costs pennies per tablet , whereas Arimidex costs $5
thats
right FIVE dollars a pill. Obviously, Tamoxifen is not a profitable
drug for Doctors and the Pharmaceutical companies to market.
In addition there are many absolutely vital nutritional products
that women must have to reduce their chances of getting Breast
Cancer. There are now thousands of research papers showing how
these natural products can benefit and help reduce the incidence
and spread of Breast Cancer.
Please feel free to contact us to discuss this information.
Disclaimer: This article represents the view
of the writers and researchers involved. It is not meant to replace
medical information you receive from your Physician.
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